PIs: Lorenzo Guglielmetti, Berit Lange, Heinke Kunst
The aim of the study is to assess whether migrant-sensitive care strategies lead to an increase of successful active TB and LTBI treatment outcomes in migrants.
A retrospective cohort study including all TB and LTBI patients seen/a random sample (depending on clinical centers availability of data and data entering resources) of TB and LTBI patients seen between 2013 and 2018 will be performed, with the following objectives:
Proportion and characteristics (including clinical presentation) of migrant TB patients (any patient not born in country of residence, differentiated by region of origin, length of stay in country, type of migration and flight route [see also attached data collection tool on patient characteristics]) over all TB (RR-TB and DS-TB) and LTBI patients including trends over time will be assessed (Aim 1).
Management strategies and operational parameters of centers recruiting TB and LTBI migrant patients will be described according to their applicability to migrant needs and differences in management and operational parameters of health care units will be described (see also attached data collection tool on center characteristics) (Aim 2).
TB treatment outcomes (WHO and simplified) and LTBI treatment completion in non-migrants and different migrant groups will be described and compared between centers and the influence of migrant-sensitive management strategies on individual TB treatment outcomes and LTBI treatment completion and difference between migrant and non-migrant treatment outcomes/treatment completion over time will be analyzed accounting for potential confounders and effect modifiers such as different group of migrants, comorbidities and adverse reaction to drugs (Aim 2).
Migrant-sensitive care and tuberculosis
treatment outcome and completion