Drug-sensitive TB (DS-TB) is treated with isoniazid, rifampicin, ethambutol, and pyrazinamide. Factors like fast-metabolizing enzymes, malabsorption, and drug interactions can influence serum drug levels. Current TB treatment guidelines recommend weight-adapted dosing without considering sex differences.
In this study, we examine drug levels of isoniazid and rifampicin in TB patients treated between 2019 and 2023 at our center focusing on sex-specific aspects.
Interestingly, rifampicin levels were significantly lower in men compared to women, despite weight-adjusted dosing.
You can find the paper here, at miru-ffm.org, the journal's homepage, or at PubMed.