MOMA_CF

Mon, 01 Jan 0001 00:00:00 +0000

Introduction: M. abscessus is a multi-drug resistant rapid-growing mycobacterium that causes difficult to treat infections. Especially, patients with predisposing lung conditions, such as cystic fibrosis, are the ones most at risk. It has also been involved in nosocomial transmission during surgical procedures. However, the existence of so-called dominant circulating clones that exist globally and are associated with higher mortality and morbidity have lead to the assumption that inter-human transmission (direct or via fomites) takes place in these NTM. It has been stipulated that this NTM undergoes similar evolutional changes as M. tuberculosis complex before becoming a exclusively pathogenic mycobacterium.

Objectives: Investigation of the genomic landscape of M. abscessus in Germany, especially among CF-patients and the search for the dominant circulating clones in a German collective.

Methods: Clinical and epidemiological data-analysis, whole genome sequencing, genotypic drug susceptibility testing.

Status: Data analysis completed

European Nucleotide Archive

Microreact project

M. abscessus on Mycobacterial Infection Research Unit

MOMA_CF