Non-tuberculous mycobacteria (NTM) can present a serious clinical threat due to their resistance to conventional antibiotics and their ability to cause persistent infections. Mycobacteriophages (MPs) are emerging as a promising therapeutic addition or alternative.
This review explores the biological characteristics, therapeutic mechanisms, and clinical potential of MPs. Based on data from in vitro studies, animal models, and human compassionate-use cases, we highlight the mycobactericidal efficacy of MPs as well as their potential to complement antibiotic treatment regimens.
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